A Polymorphism in the ??4 Nicotinic Receptor Gene (Chrna4) Modulates Enhancement of Nicotinic Receptor Function by Ethanol
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چکیده
منابع مشابه
A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol.
BACKGROUND Several studies indicate that ethanol enhances the activity of alpha4beta2 nicotinic acetylcholine receptors (nAChR). Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein. Mouse strains expressing the A variant have, in gene...
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ژورنال
عنوان ژورنال: Alcoholism: Clinical & Experimental Research
سال: 2003
ISSN: 0145-6008
DOI: 10.1097/01.alc.0000067973.41153.bc